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Geminin restrains mesendodermal fate acquisition of embryonic stem cells and is associated with antagonism of Wnt signaling and enhanced Polycomb-mediated repression
Embryonic cells utilize both growth factor signaling and cell intrinsic transcriptional and epigenetic regulation to acquire early cell fates. Underlying mechanisms that integrate these cues are poorly understood. Here we investigated the role of Geminin, a nucleoprotein that interacts with both tra...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3776023/ https://ncbi.nlm.nih.gov/pubmed/23630199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1410 |
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