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Geminin restrains mesendodermal fate acquisition of embryonic stem cells and is associated with antagonism of Wnt signaling and enhanced Polycomb-mediated repression

Embryonic cells utilize both growth factor signaling and cell intrinsic transcriptional and epigenetic regulation to acquire early cell fates. Underlying mechanisms that integrate these cues are poorly understood. Here we investigated the role of Geminin, a nucleoprotein that interacts with both tra...

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Bibliografske podrobnosti
Main Authors: Caronna, Elizabeth A., Patterson, Ethan S., Hummert, Pamela M., Kroll, Kristen L.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776023/
https://ncbi.nlm.nih.gov/pubmed/23630199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1410
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