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MST1 Promotes Apoptosis through Phosphorylation of Histone H2AX

MST1 (mammalian STE20-like kinase 1) is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis. Overexpression of MST1 induces apoptotic morphological changes such as chromatin condensation, but the mechanism is not clear. Here we show that MST1 induces apoptotic chroma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wen, Weihong, Zhu, Feng, Zhang, Jishuai, Keum, Young-Sam, Zykova, Tatyana, Yao, Ke, Peng, Cong, Zheng, Duo, Cho, Yong-Yeon, Ma, Wei-ya, Bode, Ann M., Dong, Zigang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998151/
https://ncbi.nlm.nih.gov/pubmed/20921231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.151753
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