TOPK Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells

PURPOSE: Arsenic is a valuable therapeutic tool in cancer treatment. T-LAK cell-originated protein kinase (TOPK) is highly expressed in cancer cells but its specific function is still unknown. We investigated the role of TOPK in arsenic-induced apoptosis in RPMI7951 human melanoma cells. EXPERIMENTA...

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Bibliographic Details
Main Authors:	Zykova, Tatyana A., Zhu, Feng, Lu, Chengrong, Higgins, LeeAnn, Tatsumi, Yasuaki, Abe, Yasuhito, Bode, Ann M., Dong, Zigang
Format:	Artigo
Language:	Inglês
Published:	2006
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2238807/ https://ncbi.nlm.nih.gov/pubmed/17145805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-0410
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TOPK Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells

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