Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances Internalization

The current activation model of the EGF receptor (EGFR) predicts that binding of EGF results in dimerization and oligomerization of the EGFR, leading to the allosteric activation of the intracellular tyrosine kinase. Little is known about the regulatory mechanism of receptor oligomerization. In this...

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Bibliographic Details
Main Authors: Hofman, Erik G., Bader, Arjen N., Voortman, Jarno, van den Heuvel, Dave J., Sigismund, Sara, Verkleij, Arie J., Gerritsen, Hans C., van Bergen en Henegouwen, Paul M. P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998144/
https://ncbi.nlm.nih.gov/pubmed/20940297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164731
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