Characterization of superoxide overproduction by the D-Loop(Nox4)-Nox2 cytochrome b(558) in phagocytes – Differential sensitivity to calcium and phosphorylation events

NADPH oxidase is a crucial element of phagocytes involved in microbicidal mechanisms. It becomes active when membrane-bound cytochrome b(558), the redox core, is assembled with cytosolic p47(phox), p67(phox), p40(phox), and rac proteins to produce superoxide, the precursor for generation of toxic re...

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Main Authors: Carrichon, Laure, Picciocchi, Antoine, Debeurme, Franck, Defendi, Federica, Beaumel, Sylvain, Jesaitis, Algirdas J., Dagher, Marie-Claire, Stasia, Marie-José
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997891/
https://ncbi.nlm.nih.gov/pubmed/20708598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.08.002
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