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Mechanisms underlying lineage commitment and plasticity of helper CD4(+) T cells

Upon encountering microbial pathogens, CD4(+) T cells become activated and differentiate to various subsets with distinct patterns of gene expression and profiles of cytokine production. These cells are critical for host defense, but are also major drivers of immune-mediated disease. Although classi...

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Detalhes bibliográficos
Main Authors: O'Shea, John J., Paul, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997673/
https://ncbi.nlm.nih.gov/pubmed/20185720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178334
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