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Mechanisms underlying lineage commitment and plasticity of helper CD4(+) T cells

Upon encountering microbial pathogens, CD4(+) T cells become activated and differentiate to various subsets with distinct patterns of gene expression and profiles of cytokine production. These cells are critical for host defense, but are also major drivers of immune-mediated disease. Although classi...

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Hlavní autoři: O'Shea, John J., Paul, William E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997673/
https://ncbi.nlm.nih.gov/pubmed/20185720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178334
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