A peptide switch regulates DNA polymerase processivity

Chromosomal DNA polymerases are tethered to DNA by a circular sliding clamp for high processivity. However, lagging strand synthesis requires the polymerase to rapidly dissociate on finishing each Okazaki fragment. The Escherichia coli replicase contains a subunit (τ) that promotes separation of pol...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: López de Saro, Francisco J., Georgescu, Roxana E., O'Donnell, Mike
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299760/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14630952/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2435454100
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