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A peptide switch regulates DNA polymerase processivity

Chromosomal DNA polymerases are tethered to DNA by a circular sliding clamp for high processivity. However, lagging strand synthesis requires the polymerase to rapidly dissociate on finishing each Okazaki fragment. The Escherichia coli replicase contains a subunit (τ) that promotes separation of pol...

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Autors principals: López de Saro, Francisco J., Georgescu, Roxana E., O'Donnell, Mike
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC299760/
https://ncbi.nlm.nih.gov/pubmed/14630952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2435454100
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