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A peptide switch regulates DNA polymerase processivity
Chromosomal DNA polymerases are tethered to DNA by a circular sliding clamp for high processivity. However, lagging strand synthesis requires the polymerase to rapidly dissociate on finishing each Okazaki fragment. The Escherichia coli replicase contains a subunit (τ) that promotes separation of pol...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC299760/ https://ncbi.nlm.nih.gov/pubmed/14630952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2435454100 |
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