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A peptide switch regulates DNA polymerase processivity
Chromosomal DNA polymerases are tethered to DNA by a circular sliding clamp for high processivity. However, lagging strand synthesis requires the polymerase to rapidly dissociate on finishing each Okazaki fragment. The Escherichia coli replicase contains a subunit (τ) that promotes separation of pol...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC299760/ https://ncbi.nlm.nih.gov/pubmed/14630952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2435454100 |
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