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Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
As a key cellular regulatory protein p53 is subject to tight regulation by several E3 ligases. Here we demonstrate the role of HECT domain E3 ligase, WWP1, in regulating p53 localization and activity. WWP1 associates with p53 and induces p53 ubiquitination. Unlike other E3 ligases, WWP1 increases p5...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997392/ https://ncbi.nlm.nih.gov/pubmed/16924229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1209924 |
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