Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases
The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 15...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis Group
2024-12-01
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| Col·lecció: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Matèries: | |
| Accés en línia: | https://www.tandfonline.com/doi/10.1080/14756366.2024.2394895 |
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