Regulation of p53 Localization and Activity by Ubc13

The abundance and activity of p53 are regulated largely by ubiquitin ligases. Here we demonstrate a previously undisclosed regulation of p53 localization and activity by Ubc13, an E2 ubiquitin-conjugating enzyme. While increasing p53 stability, Ubc13 decreases p53 transcriptional activity and increa...

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Bibliografiske detaljer
Main Authors: Laine, Aaron, Topisirovic, Ivan, Zhai, Dayong, Reed, John C., Borden, Katherine L. B., Ronai, Ze'ev
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636826/
https://ncbi.nlm.nih.gov/pubmed/17000756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01156-06
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