Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma

Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD), a progressive neurodegenerative disease affecting ∼10% of early-onset dementia patients. Using an enzyme-linked immunosorbent as...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Carrasquillo, Minerva M., Nicholson, Alexandra M., Finch, NiCole, Gibbs, J. Raphael, Baker, Matt, Rutherford, Nicola J., Hunter, Talisha A., DeJesus-Hernandez, Mariely, Bisceglio, Gina D., Mackenzie, Ian R., Singleton, Andrew, Cookson, Mark R., Crook, Julia E., Dillman, Allissa, Hernandez, Dena, Petersen, Ronald C., Graff-Radford, Neill R., Younkin, Steven G., Rademakers, Rosa
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2010
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997361/
https://ncbi.nlm.nih.gov/pubmed/21087763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2010.11.002
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky