Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar degeneration (FTLD) with ubiquitin and TAR DNA-binding protein 43 (TDP43)-positive pathology. The clinical presentation associated with GRN mutations is heterogeneous and may include clinical probable Alzheimer�...

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Hlavní autoři: Finch, NiCole, Baker, Matt, Crook, Richard, Swanson, Katie, Kuntz, Karen, Surtees, Rebecca, Bisceglio, Gina, Rovelet-Lecrux, Anne, Boeve, Bradley, Petersen, Ronald C., Dickson, Dennis W., Younkin, Steven G., Deramecourt, Vincent, Crook, Julia, Graff-Radford, Neill R., Rademakers, Rosa
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664450/
https://ncbi.nlm.nih.gov/pubmed/19158106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awn352
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