Nonlinear pharmacokinetics of piperacillin in healthy volunteers – implications for optimal dosage regimens

AIMS: (i) To describe the first-order and mixed-order elimination pathways of piperacillin, (ii) to determine the between occasion variability (BOV) of pharmacokinetic parameters and (iii) to propose optimized dosage regimens. METHODS: We performed a five-period replicate dose study in four healthy...

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Autors principals: Bulitta, Jürgen B, Kinzig, Martina, Jakob, Verena, Holzgrabe, Ulrike, Sörgel, Fritz, Holford, Nicholas H G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
Matèries:
Pharmacokinetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997308/
https://ncbi.nlm.nih.gov/pubmed/21039762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03750.x
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