Intracellular calcium-release and protein kinase C-activation stimulate sonic hedgehog gene expression during gastric acid secretion

INTRODUCTION: Hypochlorhydria during Helicobacter pylori infection inhibits gastric Shh expression. We investigated whether acid-secretory mechanisms regulate Shh gene expression through Ca2(+)(i)-dependent protein kinase C (PKC) or cAMP-dependent protein kinase A (PKA)-activation. METHOD: We blocke...

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Autori principali: El-Zaatari, Mohamad, Zavros, Yana, Tessier, Art, Waghray, Meghna, Lentz, Steve, Gumucio, Deborah, Todisco, Andrea, Merchant, Juanita L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997213/
https://ncbi.nlm.nih.gov/pubmed/20816837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.08.047
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