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The specificity of UV-induced mutations at an endogenous locus in mammalian cells.

We have used a rapid in vivo recombinational method to clone and completely sequence 34 UV-induced mutants at the adenine phosphoribosyltransferase (APRT) locus of Chinese hamster ovary cells. Among the mutants recovered, 26 were single base substitutions including 17 G.C----A.T transitions and a si...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Drobetsky, E A, Grosovsky, A J, Glickman, B W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299700/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3480533/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.24.9103
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