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How specificity for self-peptides shapes the development and function of regulatory T cells

The cataclysmic disease that develops in mice and humans lacking CD4(+) T cells expressing the transcription factor Foxp3 has provided abundant evidence that Foxp3(+)CD4(+) Tregs are required to suppress a latent autoreactivity of the immune system. There is also evidence for the existence of tissue...

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Autori principali: Simons, Donald M., Picca, Cristina Cozzo, Oh, Soyoung, Perng, Olivia A., Aitken, Malinda, Erikson, Jan, Caton, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Leukocyte Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996893/
https://ncbi.nlm.nih.gov/pubmed/20495071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0310183
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