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Apoptotic caspases regulate induction of iPS cells from human fibroblasts

The molecular mechanisms involved in the derivation of induced pluripotent stem cells (iPSCs) from differentiated cells are poorly understood. Here we report that caspases 3 and 8, two proteases associated with apoptotic cell death, play critical roles in induction of iPSCs from human fibroblasts. A...

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Autors principals: Li, Fang, He, Zhimin, Shen, Jingping, Huang, Qian, Li, Wenrong, Liu, Xinjian, He, Yujun, Wolf, Frank, Li, Chuan-Yuan
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996867/
https://ncbi.nlm.nih.gov/pubmed/20887956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.09.003
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