NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation have not been elucidated. Here we report that 1 h of HT activates hypoxia-inducible factor-1 (HIF...

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Bibliografische gegevens
Hoofdauteurs: Moon, Eui Jung, Sonveaux, Pierre, Porporato, Paolo E., Danhier, Pierre, Gallez, Bernard, Batinic-Haberle, Ines, Nien, Yu-Chih, Schroeder, Thies, Dewhirst, Mark W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996638/
https://ncbi.nlm.nih.gov/pubmed/21059928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006646107
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