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Role of antigen persistence and dose for CD4(+) T-cell exhaustion and recovery
It is currently not understood how some chronic infections exhaust antigen-specific T cells over time and which pathogen components contribute to exhaustion. Here, we dissected the behavior of primed CD4(+) T cells exposed to persistent antigen using an inducible transgenic mouse system that allowed...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996637/ https://ncbi.nlm.nih.gov/pubmed/21059929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008437107 |
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