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Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response

For CD8(+) T cells, a relatively short antigen pulse seems sufficient for antigen-presenting cells to drive clonal expansion and differentiation. It is unknown whether the requirement for antigen is similarly ephemeral for CD4(+) T cells. To study the dependence of a CD4(+) T cell response on antige...

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Detalhes bibliográficos
Main Authors: Obst, Reinhard, van Santen, Hisse-Martien, Mathis, Diane, Benoist, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212918/
https://ncbi.nlm.nih.gov/pubmed/15897273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042521
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