HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication

Viral infectivity factor, an accessory protein encoded in the HIV-1 genome, induces G2 cell cycle arrest; however, the biological significance and mechanism(s) remain totally unclear. Here we demonstrate that the TP53 pathway is involved in Vif-mediated G2 cell cycle arrest. Vif enhances the stabili...

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Auteurs principaux: Izumi, Taisuke, Io, Katsuhiro, Matsui, Masashi, Shirakawa, Kotaro, Shinohara, Masanobu, Nagai, Yuya, Kawahara, Masahiro, Kobayashi, Masayuki, Kondoh, Hiroshi, Misawa, Naoko, Koyanagi, Yoshio, Uchiyama, Takashi, Takaori-Kondo, Akifumi
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996458/
https://ncbi.nlm.nih.gov/pubmed/21071676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008076107
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