Mechanism of replication blocking and bypass of Y-family polymerase η by bulky acetylaminofluorene DNA adducts

Heterocyclic aromatic amines produce bulky C8 guanine lesions in vivo, which interfere and disrupt DNA and RNA synthesis. These lesions are consequently strong replication blocks. In addition bulky adducts give rise to point and frameshift mutations. The translesion synthesis (TLS) DNA polymerase η...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Schorr, Stephanie, Schneider, Sabine, Lammens, Katja, Hopfner, Karl-Peter, Carell, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996444/
https://ncbi.nlm.nih.gov/pubmed/21076032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008894107
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky