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Effect of N-2-Acetylaminofluorene and 2-Aminofluorene Adducts on DNA Binding and Synthesis by Yeast DNA Polymerase η

The well-studied aromatic amine carcinogen, N-2-acetylaminofluorene (AAF), forms adducts at the C8 position of guanine in DNA. Unlike replicative polymerases, Y-family polymerases have been shown to have the ability to bypass such bulky DNA lesions. To better understand the mechanism of translesion...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vooradi, Venkataramana, Romano, Louis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861170/
https://ncbi.nlm.nih.gov/pubmed/19354292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9000722
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