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Mechanism of replication blocking and bypass of Y-family polymerase η by bulky acetylaminofluorene DNA adducts
Heterocyclic aromatic amines produce bulky C8 guanine lesions in vivo, which interfere and disrupt DNA and RNA synthesis. These lesions are consequently strong replication blocks. In addition bulky adducts give rise to point and frameshift mutations. The translesion synthesis (TLS) DNA polymerase η...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996444/ https://ncbi.nlm.nih.gov/pubmed/21076032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008894107 |
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