In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction

S100B is highly over-expressed in many cancers, including malignant melanoma. In such cancers, S100B binds wild-type p53 in a calcium-dependent manner, sequestering it, and promoting its degradation, resulting in the loss of p53-dependent tumor suppression activities. Therefore, S100B inhibitors may...

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Main Authors: Wilder, Paul T, Charpentier, Thomas H, Liriano, Melissa A, Gianni, Kira, Varney, Kristen M, Pozharski, Edwin, Coop, Andrew, Toth, Eric A, MacKerell, Alex D, Weber, David J
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995924/
https://ncbi.nlm.nih.gov/pubmed/21132089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJHTS.S8210
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