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In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction
S100B is highly over-expressed in many cancers, including malignant melanoma. In such cancers, S100B binds wild-type p53 in a calcium-dependent manner, sequestering it, and promoting its degradation, resulting in the loss of p53-dependent tumor suppression activities. Therefore, S100B inhibitors may...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995924/ https://ncbi.nlm.nih.gov/pubmed/21132089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJHTS.S8210 |
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