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Long lasting inhibitors of the gastric H,K-ATPase
Proton pump inhibitors (PPIs) are acid-activated prodrugs which covalently bind to the gastric H,K-ATPase on its luminal surface. Only active pumps can be inhibited. The short plasma residence time of current PPIs prevents inhibition of pumps synthesized or activated after the PPI has disappeared, l...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995460/ https://ncbi.nlm.nih.gov/pubmed/21132072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/ecp.09.33 |
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