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Mechanism of N-methylation by the tRNA m(1)G37 methyltransferase Trm5

Trm5 is a eukaryal and archaeal tRNA methyltransferase that catalyzes methyl transfer from S-adenosylmethionine (AdoMet) to the N(1) position of G37 directly 3′ to the anticodon. While the biological role of m(1)G37 in enhancing translational fidelity is well established, the catalytic mechanism of...

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Autores principales: Christian, Thomas, Lahoud, Georges, Liu, Cuiping, Hoffmann, Katherine, Perona, John J., Hou, Ya-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995409/
https://ncbi.nlm.nih.gov/pubmed/20980671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2376210
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