Differentiating analogous tRNA methyltransferases by fragments of the methyl donor

Bacterial TrmD and eukaryotic-archaeal Trm5 form a pair of analogous tRNA methyltransferase that catalyze methyl transfer from S-adenosyl methionine (AdoMet) to N(1) of G37, using catalytic motifs that share no sequence or structural homology. Here we show that natural and synthetic analogs of AdoMe...

Full description

Saved in:
Bibliographic Details
Main Authors: Lahoud, Georges, Goto-Ito, Sakurako, Yoshida, Ken-ichi, Ito, Takuhiro, Yokoyama, Shigeyuki, Hou, Ya-Ming
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138561/
https://ncbi.nlm.nih.gov/pubmed/21602303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2706011
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items