Structural basis for methyl-donor–dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD

The deep trefoil knot architecture is unique to the SpoU and tRNA methyltransferase D (TrmD) (SPOUT) family of methyltransferases (MTases) in all three domains of life. In bacteria, TrmD catalyzes the N(1)-methylguanosine (m(1)G) modification at position 37 in transfer RNAs (tRNAs) with the (36)GG(3...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ito, Takuhiro, Masuda, Isao, Yoshida, Ken-ichi, Goto-Ito, Sakurako, Sekine, Shun-ichi, Suh, Se Won, Hou, Ya-Ming, Yokoyama, Shigeyuki
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534213/
https://ncbi.nlm.nih.gov/pubmed/26183229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422981112
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