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Persistence of seed-based activity following segmentation of a microRNA guide strand
microRNAs are ∼22 nucleotide regulatory RNAs that are processed into duplexes from hairpin structures and incorporated into Argonaute proteins. Here, we show that a nick in the middle of the guide strand of an miRNA sequence allows for seed-based targeting characteristic of miRNA activity. Insertion...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995395/ https://ncbi.nlm.nih.gov/pubmed/20971811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2296210 |
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