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The conformation of microRNA seed regions in native microRNPs is prearranged for presentation to mRNA targets
MicroRNAs control gene expression by post-transcriptional down-regulation of their target mRNAs. Complementarity between the seed region (nucleotides 2–8) of a microRNA and the 3′-UTR of its target mRNA is the key determinant in recognition. However, the structural basis of the ability of the seed r...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113585/ https://ncbi.nlm.nih.gov/pubmed/21335607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr077 |
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