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The conformation of microRNA seed regions in native microRNPs is prearranged for presentation to mRNA targets

MicroRNAs control gene expression by post-transcriptional down-regulation of their target mRNAs. Complementarity between the seed region (nucleotides 2–8) of a microRNA and the 3′-UTR of its target mRNA is the key determinant in recognition. However, the structural basis of the ability of the seed r...

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Bibliografiske detaljer
Main Authors: Lambert, Nicole J., Gu, Sam G., Zahler, Alan M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113585/
https://ncbi.nlm.nih.gov/pubmed/21335607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr077
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