Conformational plasticity of RNA for target recognition as revealed by the 2.15 Å crystal structure of a human IgG–aptamer complex

Aptamers are short single-stranded nucleic acids with high affinity to target molecules and are applicable to therapeutics and diagnostics. Regardless of an increasing number of reported aptamers, the structural basis of the interaction of RNA aptamer with proteins is poorly understood. Here, we det...

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Détails bibliographiques
Auteurs principaux: Nomura, Yusuke, Sugiyama, Shigeru, Sakamoto, Taiichi, Miyakawa, Shin, Adachi, Hiroaki, Takano, Kazufumi, Murakami, Satoshi, Inoue, Tsuyoshi, Mori, Yusuke, Nakamura, Yoshikazu, Matsumura, Hiroyoshi
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995045/
https://ncbi.nlm.nih.gov/pubmed/20675355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq615
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