A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch.

Hybrids formed by fusing mouse erythroleukemia (MEL) cells with human fetal erythroid cells produce human fetal globin, but they switch to adult globin production as culture time advances. To obtain information on the chromosomal assignment of the elements that control gamma-to-beta switching, we an...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Melis, M, Demopulos, G, Najfeld, V, Zhang, J W, Brice, M, Papayannopoulou, T, Stamatoyannopoulos, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299487/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.8105
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