A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch.

Hybrids formed by fusing mouse erythroleukemia (MEL) cells with human fetal erythroid cells produce human fetal globin, but they switch to adult globin production as culture time advances. To obtain information on the chromosomal assignment of the elements that control gamma-to-beta switching, we an...

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Bibliographic Details
Main Authors: Melis, M, Demopulos, G, Najfeld, V, Zhang, J W, Brice, M, Papayannopoulou, T, Stamatoyannopoulos, G
Format: Artigo
Language:Inglês
Published: 1987
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC299487/
https://ncbi.nlm.nih.gov/pubmed/3479779
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