High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone DnaK

BACKGROUND: Chaperones facilitate proper folding of peptides and bind to misfolded proteins as occurring during periods of cell stress. Complexes of peptides with chaperones induce peptide-directed immunity. Here we analyzed the interaction of (pre)proinsulin with the best characterized chaperone of...

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Main Authors: Burkart, Volker, Siegenthaler, Rahel K, Blasius, Elias, Vandenbroeck, Koen, Alloza, Iraide, Fingberg, Waltraud, Schloot, Nanette C, Christen, Philipp, Kolb, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994776/
https://ncbi.nlm.nih.gov/pubmed/21059249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-11-44
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