High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone DnaK

BACKGROUND: Chaperones facilitate proper folding of peptides and bind to misfolded proteins as occurring during periods of cell stress. Complexes of peptides with chaperones induce peptide-directed immunity. Here we analyzed the interaction of (pre)proinsulin with the best characterized chaperone of...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Burkart, Volker, Siegenthaler, Rahel K, Blasius, Elias, Vandenbroeck, Koen, Alloza, Iraide, Fingberg, Waltraud, Schloot, Nanette C, Christen, Philipp, Kolb, Hubert
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994776/
https://ncbi.nlm.nih.gov/pubmed/21059249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-11-44
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk