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The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70 kDa Heat Shock Protein DnaK in Macrophage Stimulation

BACKGROUND: Heat shock proteins (Hsp) act as intracellular chaperones and in addition are used as adjuvant in vaccines of peptides complexed with recombinant Hsp. By interacting with autologous peptides, Hsp may promote the induction of autoimmune reactivity. OBJECTIVE: Here, we analysed whether the...

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Detalhes bibliográficos
Publicado no:J Diabetes Res
Main Authors: Blasius, Elias, Gülden, Elke, Kolb, Hubert, Habich, Christiane, Burkart, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304834/
https://ncbi.nlm.nih.gov/pubmed/30622969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/4834673
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