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The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70 kDa Heat Shock Protein DnaK in Macrophage Stimulation

Background. Heat shock proteins (Hsp) act as intracellular chaperones and in addition are used as adjuvant in vaccines of peptides complexed with recombinant Hsp. By interacting with autologous peptides, Hsp may promote the induction of autoimmune reactivity. Objective. Here, we analysed whether the...

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Autors principals: Elias Blasius, Elke Gülden, Hubert Kolb, Christiane Habich, Volker Burkart
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Limited 2018-01-01
Col·lecció:Journal of Diabetes Research
Accés en línia:http://dx.doi.org/10.1155/2018/4834673
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