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Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

Epidermal growth factor (EGF) receptor monomers and noncovalently associated dimers were isolated by sucrose density gradient centrifugation, and their respective binding and autophosphorylation activities were determined. We find that monomers are low-affinity receptors and dimers are high-affinity...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Böni-Schnetzler, M, Pilch, P F
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299411/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3500470/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.7832
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