Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense

Here, we describe a new mechanism of host defense that involves the nuclear factors associated with dsRNA (NFAR1 [90 kDa] and NFAR2 [110 kDa]), which constitute part of the shuttling ribonuclear protein (RNP) complex. Activation of the dsRNA-activated protein kinase PKR by viral RNA enabled phosphor...

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Bibliographic Details
Main Authors: Harashima, Ai, Guettouche, Toumy, Barber, Glen N.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994038/
https://ncbi.nlm.nih.gov/pubmed/21123651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1965010
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