Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

Adoptive transfer of genetically modified T cells is an attractive approach for generating antitumor immune responses. We treated a patient with advanced follicular lymphoma by administering a preparative chemotherapy regimen followed by autologous T cells genetically engineered to express a chimeri...

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Autori principali: Kochenderfer, James N., Wilson, Wyndham H., Janik, John E., Dudley, Mark E., Stetler-Stevenson, Maryalice, Feldman, Steven A., Maric, Irina, Raffeld, Mark, Nathan, Debbie-Ann N., Lanier, Brock J., Morgan, Richard A., Rosenberg, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993617/
https://ncbi.nlm.nih.gov/pubmed/20668228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281931
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