Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice

Th17 cells promote a variety of autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. TGF-β is required for conversion of naive T cells to Th17 cells, but the mechanisms regulating this process are unknown. Integrin αvβ8 on DCs can activa...

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Main Authors: Melton, Andrew C., Bailey-Bucktrout, Samantha L., Travis, Mark A., Fife, Brian T., Bluestone, Jeffrey A., Sheppard, Dean
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2010
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993595/
https://ncbi.nlm.nih.gov/pubmed/21099117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43786
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