Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

CD4(+)CD25(+)Foxp3(+) Tregs play a major role in prevention of autoimmune diseases. The suppressive effect of Tregs on effector T cells (Teffs), the cells that can mediate autoimmunity, has been extensively studied. However, the in vivo impact of Teff activation on Tregs during autoimmunity has not...

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Main Authors: Grinberg-Bleyer, Yenkel, Saadoun, David, Baeyens, Audrey, Billiard, Fabienne, Goldstein, Jérémie D., Grégoire, Sylvie, Martin, Gaëlle H., Elhage, Rima, Derian, Nicolas, Carpentier, Wassila, Marodon, Gilles, Klatzmann, David, Piaggio, Eliane, Salomon, Benoît L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993590/
https://ncbi.nlm.nih.gov/pubmed/21099113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42945
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