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Tumor emergence is sensed by self-specific CD44(hi) memory Tregs that create a dominant tolerogenic environment for tumors in mice
Early responses of Tregs and effector T cells (Teffs) to their first encounter with tumor cells have been poorly characterized. Here we have shown, in both implanted and in situ–induced mouse tumor models, that the appearance of tumor cells is immediately sensed by CD44(hi) memory Tregs that are spe...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735938/ https://ncbi.nlm.nih.gov/pubmed/19652360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36628 |
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