IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

Regulatory T cells (T reg cells) play a major role in controlling the pathogenic autoimmune process in type 1 diabetes (T1D). Interleukin 2 (IL-2), a cytokine which promotes T reg cell survival and function, may thus have therapeutic efficacy in T1D. We show that 5 d of low-dose IL-2 administration...

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Detalhes bibliográficos
Main Authors: Grinberg-Bleyer, Yenkel, Baeyens, Audrey, You, Sylvaine, Elhage, Rima, Fourcade, Gwladys, Gregoire, Sylvie, Cagnard, Nicolas, Carpentier, Wassila, Tang, Qizhi, Bluestone, Jeffrey, Chatenoud, Lucienne, Klatzmann, David, Salomon, Benoît L., Piaggio, Eliane
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931175/
https://ncbi.nlm.nih.gov/pubmed/20679400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100209
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